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Association of polymorphisms of human leucocyte antigen‐DQA1 and DQB1 alleles with chronic hepatitis B virus infection, liver cirrhosis and hepatocellular carcinoma in Chinese
Author(s) -
Liu C.,
Cheng B.
Publication year - 2007
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2007.00702.x
Subject(s) - hepatocellular carcinoma , hepatitis b virus , cirrhosis , human leukocyte antigen , virus , hla dqb1 , allele , hepatitis c virus , medicine , immunology , virology , biology , antigen , gene , gastroenterology , genetics
Summary To investigate whether human leucocyte antigen (HLA) class II DQA1 and DQB1 gene polymorphisms are associated with chronic hepatitis B virus (HBV) infection and development of HBV‐related liver cirrhosis (LC) and hepatocellular carcinoma (HCC), we detected the DQA1 and DQB1 allele polymorphisms in 168 HBV carriers (including 48 chronic hepatitis B, 42 LC and 78 HCC patients) and 100 controls who had recovered from HBV infection by using polymerase chain reaction amplification with sequence‐specific primers (PCR‐SSP). Our data suggest that DQA1*0102 and DQA1*0104 were associated with protection from chronic HBV infection ( P c = 0.003) and development of LC ( P c = 0.001), respectively, whereas DQB1*0201 conferred susceptible effect on chronic HBV infection ( P c = 0.008). We also found that DQA1*0601, DQB1*0601 and DQA1*0201 showed some susceptible effect on chronic HBV infection and LC, respectively, however, these associations were no longer significant after Bonferroni correction ( P c = 0.390, P c = 0.475 and P c = 0.140, respectively). No significant association has been found between DQA1 and DQB1 alleles and development of HCC. These results indicate that different subtypes of HLA‐DQA1 and DQB1 are associated with development of chronic HBV infection and LC, respectively, in Han Chinese population.