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The FcγRIIa polymorphism influences production of interleukin‐1 by mononuclear cells
Author(s) -
Yamamoto K.,
Kobayashi T.,
Sugita N.,
Tai H.,
Yoshie H.
Publication year - 2007
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2007.00701.x
Subject(s) - peripheral blood mononuclear cell , genotype , flow cytometry , immunology , cd14 , receptor , antibody , stimulation , biology , interleukin , cytokine , gene , in vitro , genetics , endocrinology
Summary The functional bi‐allelic polymorphism of immunoglobulin G (IgG) Fc receptor (FcγR) IIa influences the efficiency of human IgG2 binding. Our previous study showed that the high affinity FcγRIIa genotype (‐H/H131) was associated with periodontitis risk. As interleukin‐1 (IL‐1) is one of the major causes of periodontal tissue destruction, it is hypothesized that the FcγRIIa‐H/H131cross‐linking could induce an increased IL‐1 release by mononuclear cells. In this study, we evaluated the intracellular expressions of IL‐1β in CD14 positive cells upon stimulation with human IgG2 by flow cytometry. FcγRIIa‐H/H131 subjects exhibited a higher percentage of IL‐1β‐producing cells than FcγRIIa‐R/H131 and ‐R/R131 subjects ( P < 0.05). These results support the concept that FcγRIIa genotype may affect IL‐1β production, possibly leading to interindividual differences in periodontitis risk.