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Influences of MxA gene –88 G/T and IFN‐gamma +874 A/T on the natural history of hepatitis B virus infection in an endemic area
Author(s) -
Peng X. M.,
Lei R. X.,
Gu L.,
Ma H. H.,
Xie Q. F.,
Gao Z. L.
Publication year - 2007
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2007.00696.x
Subject(s) - genotype , hbsag , hepatitis b virus , single nucleotide polymorphism , virology , immunology , biology , interferon , polymerase chain reaction , natural history , interferon gamma , virus , gene , medicine , genetics , immune system
Summary The influence of human genetics on the natural history of hepatitis B virus (HBV) infection may be diminished in endemic areas because infection at a young age predisposes to chronic HBV infection. The present study aimed to address this issue through the determination of the influences of single nucleotide polymorphisms (SNPs) of myxovirus resistence‐1 (MxA) –88 G/T and interferon (IFN)‐gamma +874 A/T on the natural history of HBV infection in endemic regions. One hundred adult patients with self‐limiting HBV infection (positive for both anti‐HBs and anti‐HBc) and 340 adult patients with persistent HBV infection were recruited from southern China, an endemic area with an HBsAg carrier rate of 17.8%. SNPs of MxA –88 G/T and interferon (IFN)‐gamma +874 A/T were typed using a protocol based on competitively differentiated polymerase chain reaction. A highly significant difference in the distribution of MxA –88 G/T was observed between those with persistent and self‐limiting HBV infections. The latter displayed a lower frequency of the GG genotype (41.0% vs. 52.9%, P = 0.036) and a higher frequency of the TT genotype (16.0% vs. 2.4%, P = 0.000), compared to patients with persistent infection. These differences were not gender‐ or age‐specific. However, a significant distribution difference of IFN‐gamma +874 A/T was not observed. Between two groups of patients, respectively, the distribution frequencies of the AA genotype (65.0% vs. 72.8%, P = 0.139) and the TT genotype (2.0% vs. 1.2%, P = 0.894) were found. These results suggest that MxA gene –88 G/T and IFN‐gamma +874 A/T behave differently in endemic HBV infections. Further study is necessary to clarify the influences of human genetics on endemic HBV infections.