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Identification of two novel HLA‐DRB1*11 alleles (DRB1*110404 and DRB1*1161) in two Italian cord blood units
Author(s) -
Longhi E.,
Frison S.,
Serafini M.,
Karpasitou K.,
Poli F.
Publication year - 2007
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2007.00692.x
Subject(s) - exon , genetics , allele , biology , hla drb1 , sequence (biology) , mutation , human leukocyte antigen , amino acid substitution , gene , antigen
Summary We describe the isolation and characterization of two novel HLA‐DRB1*11 alleles, officially named DRB1*1161 and 110404. These two new variants were both identified in two Caucasoid individuals. The exon 2 sequence of DRB1*1161 is identical to that of DRB1*110101 except at codon 41, where a nucleotide substitution (GAC>AAC) is responsible for an amino‐acidic change from Asp to Asn. The exon 2 sequence of the second novel allele described here, DRB1*110404, differs from that of DRB1*110401 only at codon 34 where the nucleotidic change CAA>CAG gives rise to a silent mutation.