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Sequence‐based typing of a novel HLA‐DRB1*04 allele, DRB1*0461, in a Taiwanese volunteer marrow donor
Author(s) -
Chen M. J.,
Chu C. C.,
Lin P. Y.,
Yang K. L.
Publication year - 2007
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2007.00690.x
Subject(s) - amino acid , allele , genetics , gene , microbiology and biotechnology , hla drb1 , human leukocyte antigen , chemistry , peptide sequence , biology , biochemistry , antigen
Summary We report here a novel HLA‐DRB1 allele, DRB1*0461, discovered in a Taiwanese volunteer marrow donor. The new sequence has nucleotide variation at positions 260 (C→A) and 261 (C→G), i.e. codon 58, as compared to DRB1*0408. Nucleotide change caused an amino acid substitution from alanine to glutamic acid. We believe that the gene conversion took place between DRB1*0405 and DRB1*1101 based on sequence homology and gene frequency in population studies. In comparison to DRB1*0405, DRB1*0461 has two amino acid changes at codons 57 and 58. Amino acid residue substitution at position 57 may affect peptide‐binding environment at pocket P9 of the antigen‐binding groove of the MHC molecule. This would have potential effect in peptide binding as well as in T‐cell recognition, which could have clinical significance in bone marrow and organ transplantations.