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COX‐2 promoter region polymorphisms in multiple sclerosis: lack of association of −765G>C with disease risk
Author(s) -
Mazzola S.,
Lira M. Gomez,
Benedetti M. D.,
Salviati A.,
Ottaviani S.,
Malerba G.,
Ortombina M.,
Pignatti P. F.
Publication year - 2007
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2007.00675.x
Subject(s) - multiple sclerosis , genotyping , gene , cyclooxygenase , disease , genetics , biology , genotype , medicine , immunology , enzyme , biochemistry
Summary Cyclooxygenase‐2 (COX‐2) is extensively expressed in multiple sclerosis lesions suggesting that regulatory variants of the COX‐2 gene could be implicated in multiple sclerosis (MS). Screening of the proximal 5′ regulatory region and genotyping of −765G>C and −62C>G showed that polymorphisms in this COX‐2 region are unlikely to be involved in MS susceptibility.