Premium
A diplotype in the lymphotoxin alpha gene is associated with differential expression of LTA mRNA induced by Gram‐positive and Gram‐negative bacteria
Author(s) -
Temple S. E. L.,
Almeida C. M.,
Cheong K. Y.,
Wunderink R. G.,
Waterer G. W.
Publication year - 2007
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2007.00674.x
Subject(s) - lymphotoxin , lymphotoxin alpha , messenger rna , gram , biology , gram negative bacteria , gene , microbiology and biotechnology , bacteria , alpha (finance) , tumor necrosis factor alpha , genetics , immunology , medicine , escherichia coli , nursing , patient satisfaction , construct validity
Summary We sequenced the lymphotoxin alpha (LTA) promoter and identified LTA10G>A in strong linkage with LTA252G>A and LTA723C>A. Stimulated cells from LTA723AA: LTA252GG:LTA10AA individuals had significantly higher LTA mRNA levels than LTA723CC:LTA252AA:LTA10GG and LTA723AA:LTA252AG:LTA10GA individuals, suggesting that this diplotype may contain a functional polymorphism explaining the observed disease associations with LTA252G>A.