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Association between genetic polymorphisms in the human interleukin‐7 receptor α‐chain and inhalation allergy
Author(s) -
Shamim Z.,
Müller K.,
Svejgaard A.,
Poulsen L. K.,
Bodtger U.,
Ryder L. P.
Publication year - 2007
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2007.00657.x
Subject(s) - thymic stromal lymphopoietin , immunology , allele , cytokine , allergy , interleukin , receptor , biology , gene , genetics
Summary Thymic stromal‐derived lymphopoietin (TSLP) and interleukin‐7 share a common receptor chain, IL‐7Rα. IL‐7 is involved in T‐cell homeostasis, and TSLP induces production of pro‐allergic cytokines. The gene encoding the IL‐7Rα chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.