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Sequencing‐based analysis of the HLA‐DPB1 polymorphism in Nu ethnic group of south‐west China
Author(s) -
Hu W.,
Wang J.,
Wang B.,
Lu J.,
Li H.,
Zhang J.,
Cun Y.,
Tang W.,
Xiao C.
Publication year - 2006
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2006.00638.x
Subject(s) - ethnic group , human leukocyte antigen , typing , allele , polymerase chain reaction , china , genetics , population , biology , demography , gene , geography , antigen , anthropology , sociology , archaeology
In the present study, DNA typing for HLA‐DPB1 was performed using polymerase chain reaction–sequencing‐based typing method in 72 randomly selected Nu ethnic individuals inhabiting the Yunnan province of south‐west China. Among the 12 detected DPB1 alleles, the most frequent was DPB1*1301, with the percentage of 20.83%, followed by DPB1*0501 (19.44%), DPB1*040101 (16.67%) and DPB1*2801 (9.72%). The allele DPB1*1501 was found for the first time in the Chinese population. Neighbour‐joining showed that the Nu ethnic minority belonged to East Asian cluster and was most closely related to Lisu, being consistent with the historical records. In addition, the results obtained in this study will also provide useful information on organ transplantation, forensic investigations and disease association studies.