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A novel HLA‐B allele, B*5612, identified by sequence‐based typing method
Author(s) -
Chu CC.,
Chang HL.,
Chen ZS.,
Lee HL.,
Lin M.
Publication year - 2006
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2006.00619.x
Subject(s) - exon , genetics , typing , biology , allele , hla b , human leukocyte antigen , sequence (biology) , gene , microbiology and biotechnology , antigen
Summary HLA‐B*5612, found in Taiwan using sequence‐based typing method, was identical to HLA‐B*5502 in exon 2 but differed in exon 3 by 10 nucleotide substitutions at positions 353–420 leading to five amino acid change at codon 94, 95, 97, 103 and 116. As this sequence motif was not found in the Asian population, it is likely that HLA‐B*5612 is the product of a complex mechanism of implying a dual gene conversion event.