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Global distribution of a novel trinucleotide microsatellite polymorphism (ATA) n in intron 8 of the SLC11A1 gene and susceptibility to pulmonary tuberculosis
Author(s) -
Awomoyi A.,
Sirugo G.,
Newport M. J.,
Tishkoff S.
Publication year - 2006
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2006.00547.x
Subject(s) - microsatellite , allele , biology , genetics , intron , polymorphism (computer science) , allele frequency , gene , tuberculosis , population , pulmonary tuberculosis , cord blood , genotype , medicine , pathology , environmental health
Summary We identified a novel trinucleotide (ATA) n repeat polymorphism in intron 8 of SLC11AI , a candidate gene for susceptibility to tuberculosis (TB) infection. We characterized the frequency of this polymorphism in 485 individuals originating from eight globally diverse human populations and compared the distribution of (ATA) n alleles in 146 adults and in 80 cord blood samples from newborns in the Gambian population. Lastly, we tested for association of this microsatellite with pulmonary TB in 318 TB cases and 146 controls in the Gambian population. We found no significant difference in frequency or distribution of alleles in adult and cord blood samples, and we found no significant association between this marker and pulmonary TB.