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Alternative splicing of IL‐24 in melanocytes by deletion of exons 3 and 5
Author(s) -
Allen M.,
Pratscher B.,
Krepler C.,
Frei K.,
Schöfer C.,
Pehamberger H.,
Müller M.,
Lucas T.
Publication year - 2005
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2005.00540.x
Subject(s) - exon , alternative splicing , gene , biology , splice , homologous chromosome , polymerase chain reaction , genetics , rna splicing , microbiology and biotechnology , cloning (programming) , exon skipping , rna , computer science , programming language
Summary Two novel interleukin‐24 (IL‐24) splice variants were identified in normal human melanocytes by sequencing cloned polymerase chain reaction (PCR) products that are not expressed in metastatic melanoma. These gene products have been generated by differential skipping of exons 3 (IL‐24 delE3) and 5 (IL‐24 delE5). IL‐24 delE3 has limited sequence identity to the IL‐24‐interacting protein mda‐7s, and IL‐24 delE5 is homologous to IL‐24.