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Association of MHC class I chain related gene‐A microsatellite polymorphism with the susceptibility to T1DM and LADA in Czech adult patients
Author(s) -
Novota P.,
Kolostova K.,
Pinterova D.,
Novak J.,
Weber P.,
Treslova L.,
Kovar J.,
Andel M.,
Cerna M.
Publication year - 2005
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2005.00532.x
Subject(s) - microsatellite , allele , polymorphism (computer science) , genetic predisposition , genetics , czech , type 1 diabetes , biology , human leukocyte antigen , gene , immunology , diabetes mellitus , antigen , endocrinology , linguistics , philosophy
Summary The results in this study suggest that microsatellite polymorphism within the transmembrane region of MIC‐A gene is associated with genetic susceptibility to adult‐onset of type 1 diabetes mellitus (T1DM), MIC‐A5.1 allele, corrected P = 0.001, whereas it is not associated with latent autoimmune diabetes in adults (LADA) in Czech population. According to our findings, we can hypothesize that adult‐onset T1DM and LADA may have partly different immunogenetic aetiopathogenesis.