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DEVELOPMENTAL EXPRESSION OF THE MOUSE MHC Q GENES
Author(s) -
Wang Q.,
Flaherty L.
Publication year - 1996
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1996.tb00273.x
Subject(s) - biology , gene , major histocompatibility complex , gene expression , genetics , embryo , histocompatibility , epithelium , microbiology and biotechnology , antigen , human leukocyte antigen
SUMMARY To investigate the role of class lb genes in the Q region of the mouse major histocompatibility complex (MHC), the developmental expression and foetal tissue distribution of the Q genes were studied in the C57BL/6 mouse. Using RNase protection assays, we examined Q gene expression in a wide spectrum of foetal tissues at different stages of gestation. Q4, Q6 and Q8 were widely expressed in a variety of tissues. In contrast, the expression of Q1 was restricted to the thymus and intestinal epithelium.