Premium
IMMUNOGENETIC FACTORS IN HPV‐ASSOCIATED CERVICAL CANCER: INFLUENCE ON DISEASE PROGRESSION
Author(s) -
DugganKeen M. F.,
Keating P. J.,
Stevens F. R. A.,
Sinnott P.,
Snijders P. J. F.,
Walboomers J. M. M.,
Davidson S.,
Hunter R. D.,
Dyer P. A.,
Stern P. L.
Publication year - 1996
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1996.tb00123.x
Subject(s) - cervical cancer , human leukocyte antigen , genotype , allele , disease , medicine , cancer , immunology , oncology , biology , genetics , antigen , gene
SUMMARY No HLA allele or specificity was significantly different in frequency between a group of 150 cervical cancer patients from north‐west England and controls (corrected P values). HLA‐DRB 1*1501/DQB 1*0602 was non‐significantly increased, particularly among patients with HPV16‐positive tumours. HLA‐B7‐positive patients had a significantly poorer clinical outcome than HLA‐B7‐negative patients. A significant component of the genotypic effect is down‐regulation of HLA‐B7 expression by the tumour cells.