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C4 NULL ALLELES IN A SWEDISH POPULATION
Author(s) -
Nityanand S.,
Dawkins R.L.,
Lithell. H.,
HOLM G.,
Lefvert A.K.
Publication year - 1995
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1995.tb00281.x
Subject(s) - biology , allele , population , null allele , null hypothesis , genetics , allele frequency , demography , gene , statistics , sociology , mathematics
SUMMARY The distribution of C4 null alleles (C4Q0) was studied in a Swedish population comprising 410 male individuals from Stockholm County and Uppsala City. The prevalances of homozygous C4A*Q0 and C4B*Q0 determined by analysing the gene products in serum were 5.0 and 5.6%, respectively, in the Stockholm population and 4.0% each in the Uppsala population. These values are higher than those previously reported from other Caucasian populations. The finding reflects a different genetic composition of the Swedish population and may have relevance to the disease spectrum in this population as compared to other Caucasian populations.