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A NOVEL TaqI/DQA RFLP ASSOCIATED WITH HLA‐DR9, DQ9 (DQA1* 0302)
Author(s) -
Vilches C.,
Pablo R.,
Solias R.,
Martin R.,
Herrero M. J.,
Moreno M. E.,
Kreisler M.
Publication year - 1995
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1995.tb00240.x
Subject(s) - taqi , restriction fragment length polymorphism , haplotype , genetics , allele , fragment (logic) , hla dq , human leukocyte antigen , biology , microbiology and biotechnology , mathematics , antigen , gene , polymerase chain reaction , algorithm
A new TaqI/DQA restriction fragment length polymorphism (RFLP) has been found in two Spanish Caucasoid individuals. The novel polymorphic fragment has a relative mobility of 4.2 kb and is associated with an HLA-A2,Cw*1401,B51,DR9,DR53,DQ9 haplotype. Nucleotide sequence analysis indicates that individuals showing this RFLP pattern do not carry a new DQA1 allele, but that (DQA1*0302) commonly observed in DR9,DQ9 haplotypes. The new RFLP seems to be a locally restricted marker of uncertain origin.