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IMMUNOGENETIC ANALYSIS OF HLA‐DR10 HOMOZYGOUS INDIVIDUALS
Author(s) -
Young N. T.,
Thompson J.,
Gibson K.,
Dewar K.,
Darke C.
Publication year - 1995
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1995.tb00230.x
Subject(s) - human leukocyte antigen , biology , genetics , immunology , evolutionary biology , antigen
SUMMARY Molecular, cellular and serological analysis of Major Histocompatibility Complex alleles was performed on three individuals who appeared to be HLA‐DR10 homozygous by DNA restriction fragment analysis. Each donor was of different ethnic origin: Caucasoid, Asian Indian and African Negroid. The results of our studies show that the Caucasoid and Asian donors are indeed homozygous for the HLA‐DR 10 allele, while the African donor also possesses the DRB1*0103 allele. Homozygosity for the HLA‐A1B37‐Cw6‐DR10‐DQ5 haplotype in the Caucasoid donor was confirmed by familial segregation analysis. The B‐lymphoblastoid cell line produced from this donor should prove useful in studies of HLA immunogenetics.