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ABSENCE OF TAP 2D IN YORUBA NIGERIANS
Author(s) -
Awomoyi A. A. O.,
Donn R. P.,
Davies E. J.,
Carthy D.,
Thomson W.,
Ollier W. E. R.
Publication year - 1995
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1995.tb00229.x
Subject(s) - nigerians , yoruba , allele , tap water , population , allele frequency , linkage disequilibrium , genetics , medicine , biology , haplotype , environmental health , political science , linguistics , law , philosophy , environmental engineering , gene , engineering
SUMMARY We have characterized TAP allele frequencies in a panel of 71 Yoruba Nigerians using ARMS‐PCR. With the exception that TAP 2D was absent in Nigerians, TAP 2 allele frequencies in this population were found to be similar to those in a UK white population. HLA‐DR4 also was found to be at a low frequency in Yoruba Nigerians (1.4%). This may reflect the absence of TAP 2D in Nigerians as DR4 and TAP 2D are in linkage disequilibrium in UK Caucasoids. The most frequent TAP 1 allele in Yoruba Nigerians was TAP 1A (49%). However, this value will be an underestimate as TAP1 alleles could not be unequivocally assigned in 41 % of subjects using the ARMS‐PCR methodology.