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POLYMORPHISM OF THE TUMOUR NECROSIS FACTOR BETA GENE IN MULTIPLE SCLEROSIS AND RHEUMATOID ARTHRITIS
Author(s) -
Vandeyver C.,
Raus P.,
Stinissen P.,
Philippaerts L.,
Cassiman J.J.,
Raus J.
Publication year - 1994
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1994.tb00208.x
Subject(s) - rheumatoid arthritis , tumor necrosis factor alpha , multiple sclerosis , medicine , necrosis , gene , immunology , beta (programming language) , pathology , biology , genetics , computer science , programming language
SUMMARY We evaluated the TNF‐ß gene polymorphism in two HLA‐associated autoimmune diseases, multiple sclerosis (MS) and rheumatoid arthritis (RA). The TNF‐β allele and genotype frequencies were not significantly different in the patient populations, compared to controls. An increased frequency of the TNF‐β* 2 allele was observed in HLA‐DR2 + vs. HLA‐DR2 ‐ MS patients. No such association was seen in HLA‐DR4 + RA patients.