THE INDUCIBLE FORM OF NITRIC OXIDE SYNTHASE (NOS2) ISOLATED FROM MURINE MACROPHAGES MAPS NEAR THE NUDE MUTATION ON MOUSE CHROMOSOME 11 | Zendy

Mock B. A. | Zendy; Krall M. M. | Zendy; Byrd L. G. | Zendy; Chin H. | Zendy; Barton C. H. | Zendy; Charles I. | Zendy; Liew F. Y. | Zendy; Blackwell J. | Zendy

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THE INDUCIBLE FORM OF NITRIC OXIDE SYNTHASE (NOS2) ISOLATED FROM MURINE MACROPHAGES MAPS NEAR THE NUDE MUTATION ON MOUSE CHROMOSOME 11

Author(s) -

Mock B. A.,

Krall M. M.,

Byrd L. G.,

Chin H.,

Barton C. H.,

Charles I.,

Liew F. Y.,

Blackwell J.

Publication year - 1994

Publication title -

international journal of immunogenetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.41

H-Index - 47

eISSN - 1744-313X

pISSN - 1744-3121

DOI - 10.1111/j.1744-313x.1994.tb00196.x

Subject(s) - nitric oxide synthase , microbiology and biotechnology , complementary dna , nitric oxide , biology , mutation , chromosome , gene , macrophage , genetics , in vitro , endocrinology

SUMMARY Nitric oxide synthase has been shown to mediate streptozocin‐induced diabetes and to act as an antimicrobial agent in murine macrophages. Using a cDNA probe for the inducible form of nitric oxide synthase ( Nos2 ) isolated from murine macrophages we have determined that the gene maps within 1 cM of the nude mutation on mouse Chromosome 11. The position of Nos2 was also mapped relative to the markers 115, Evi 2, Cchlbl (previously unmapped), and Gfap. This map location is discussed relative to map locations for disease susceptibility loci involved in mediating cutaneous leishmaniasis ( Sell ) and autoimmune type‐I diabetes ( Idd4 ).

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