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GENOMIC STRUCTURE AND ORGANIZATION OF A Q‐LIKE GENE IN THE GRC‐GIC REGION OF THE RAT
Author(s) -
Rushton J. J.,
Misra D. N.,
Kunz H. W.,
Cortese Hassett A. L.,
Gill T. J.
Publication year - 1994
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1994.tb00190.x
Subject(s) - gene , biology , exon , genetics , transmembrane protein , microbiology and biotechnology , transmembrane domain , untranslated region , messenger rna , receptor
SUMMARY In the rat homologue of the mouse Q/TL region, grc‐G/C , a TL ‐like gene ( RT1.N ) has been identified recently. This paper reports on a Q ‐like gene, designated RT1.0 , that maps in the same region. It contains a 5’ untranslated region (UT), signal peptide, α3 domain, transmembrane region, cytoplasmic domain (three exons) and 3′ UT region. Comparison with mouse class‐I genes shows that the greatest similarity is to the H‐2Q, K, D and L genes; it is very different from the TL genes of the mouse and rat. A sequence that includes many CT repeats occurs in the 3′UT region of RT1.0 and in three to five other class I‐hybridizing fragments. Thus, the MHC‐linked region of the rat contains both Q ‐like and TL ‐like class‐I genes.