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DISTRIBUTION OF HLA‐A*28 ALLELES IN A SPANISH POPULATION
Author(s) -
Yélamos J.,
González M. F.,
GarcéaLozano J. R.,
Sánchez B.
Publication year - 1994
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1994.tb00181.x
Subject(s) - biology , allele , human leukocyte antigen , genetics , population , evolutionary biology , demography , antigen , gene , sociology
SUMMARY DNA oligotyping was used to determine HLA‐A28 subtypes in 25 unrelated Caucasian individuals living in or around Seville, Spain. Results showed that HLA‐A*6802 was the most frequent allele, found in 14 individuals (53.8%), followed by HLA‐68.3, which was present in eight subjects (30.8%), and both combined represented 84.6% of A28 + individuals in the area. The HLA‐A*6801 allele was found in three individuals (11.5%), whereas HLA‐A*6901 was present in one subject only (3.8%). Results indicate that the distribution of HLA‐A28 alleles can vary among different Caucasoid populations. In this way, the high frequency obtained for A*6802 supports previous studies suggesting that the HLA‐A*6802 allele was prevalent in people of the Mediterranean basin, in contrast to A*6801, prevalent in northern European populations.