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HSP70‐Hom NcoI POLYMORPHISM AND HLA‐ASSOCIATIONS IN THE FINNISH POPULATION AND IN PATIENTS WITH ANKYLOSING SPONDYLITIS OR REACTIVE ARTHRITIS
Author(s) -
Westman P.,
Partanen J.,
LeirisaloRepo M.,
Koskimies S.
Publication year - 1994
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1994.tb00179.x
Subject(s) - ankylosing spondylitis , haplotype , allele , immunology , biology , genetics , reactive arthritis , human leukocyte antigen , major histocompatibility complex , pathogenesis , population , polymorphism (computer science) , arthritis , medicine , gene , antigen , environmental health
SUMMARY The Nco I polymorphism of the HSP70‐Hom gene was investigated in the Finnish population and in two HLA‐B27‐associated autoimmune diseases. The two HSP70‐Hom alleles were shown to be strongly associated to some specific HLA‐B/DR haplotypes in random Finnish population and the segregation of the alleles as a part of these haplotypes was confirmed in 18 families. In addition, the HSP70‐Hom alleles of 31 patients with ankylosing spondylitis (AS) and 38 with reactive arthritis (ReA) were compared with each other and with 56 unrelated healthy HLA‐B27 positive individuals. The results indicated that the HSP70‐Hom polymorphic variation is not connected independently to the different pathogenesis of AS and ReA, as no statistically significant differences between the patient groups and/or controls could be found. The HSP70‐Hom status was investigated also in 28 homozygous HLA typing cells and when compared with previously published results of HSP70‐1 and HSP0‐2 polymorphisms, it appeared that these three MHC Class‐III linked HSP70 genes segregated in fixed allelic combinations.