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SEROLOGICAL IDENTIFICATION OF A NEW HLA‐B7 VARIANT ANTIGEN –HLA‐B7QUI
Author(s) -
Fussell H.,
Thomas M.,
Street J.,
Darke C.
Publication year - 1994
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1994.tb00173.x
Subject(s) - human leukocyte antigen , antigen , immunology , haplotype , antiserum , histocompatibility , major histocompatibility complex , biology , cytotoxic t cell , serology , allele , gene , genetics , antibody , in vitro
SUMMARY A new HLA‐B antigen, HLA‐B7Qui that appears to be a variant of HLA‐B7 has been identified. This antigen, which is HLA‐Bw6 associated, reacts with approximately two‐thirds of cytotoxic antisera stimulated by HLA‐B7 or B27 that lack a B27 or B7 component, respectively. All anti‐B7+27 antisera (stimulated by either B7 or B27) react with B7Qui as do most B22‐stimulated sera possessing a B7 component. However, sera stimulated by B60, with or without a B7 component, fail to react with B7Qui. Family studies show the B7Qui allele to be unique to the haplotype –HLA‐A32 CW6 B7Qui Bf*S C4A*6 C4B*1 DR11 DQ7 (GL02). Six Caucasoid subjects on the panel of 6861 HLA‐typed potential bone marrow donors have this antigen (phenotype frequency, 0.08745%; gene frequency, 0.04473%). Work undertaken during the 11th International Histocompatibility Workshop (Reekers et al. , 1992) showed that B7Qui has the same isoelectric point as HLA‐B702 and HLA‐B703 (Bpot) and that B7Qui is distinct from the HLA‐B7 variants B703, B7SL, BDT, B7x40, BRI, and B41v.