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MAJOR HISTOCOMPATIBILITY COMPLEX LOCATED COMPLEMENT C4 AND STEROID 21‐HYDROXYLASE GENE REARRANGEMENTS IN COUPLES WITH RECURRENT SPONTANEOUS ABORTIONS
Author(s) -
Laitinen T.,
Lokki M.L.,
Partanen J.,
Tulppala M.,
Ylikorkala O.,
Koskimies S.
Publication year - 1992
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1992.tb00084.x
Subject(s) - biology , restriction fragment length polymorphism , gene duplication , genetics , major histocompatibility complex , gene , haplotype , complement (music) , allele , polymerase chain reaction , phenotype , complementation
SUMMARY Major Histocompatibility Complex (MHC) class III located complement C4 and steroid 21‐hydroxylase (21OH) genes, which form various deletion and duplication units, were studied by Taq I Restriction Fragment Length Polymorphism (RFLP) in 58 Finnish couples who suffered recurrent spontaneous abortions (RSA). The gene rearrangements found in the RSA couples did not differ from those in the controls.