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TWELVE HLA‐DR6‐RELATED DRB1 ALLELES AND ASSOCIATED DR, DQ HAPLOTYPES IN TRADITIONAL AUSTRALIANS AND OTHER POPULATIONS OF ASIA‐OCEANIA
Author(s) -
Gao X.,
Serjeantson S. W.
Publication year - 1992
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1992.tb00069.x
Subject(s) - haplotype , allele , human leukocyte antigen , genetics , biology , population , evolutionary biology , gene , medicine , antigen , environmental health
SUMMARY The relative distributions of 12 HLA‐DR6‐related HLA‐DRB1 alleles in indigenous populations of Australia, Melanesia, Polynesia, Micronesia, and northern and southern China have been determined by analysis of nucleotide sequence polymorphisms in 364 examples of HLA‐DR6 positive chromosomes. Oligonucleotide hybridizations of polymerase chain reaction products of HLA‐DQA1, DQB1, DRB1 and DRB3 genes generated 24 HLA‐DR6‐related haplotypes. The study aimed to determine the regional distribution of DR DQ haplotypes associated with three novel HLA‐DR6 alleles, namely DRB1*1408, 1409, and 1410, known to occur in Australian Aborigines, to gain further insights into the molecular phylogeny of these alleles. DRB1*1408 was the most common HLA‐DR6 subtype in Oceania, although it was not detected in Chinese. In Australian Aborigines and Papua New Guinean highlanders, DRB1*1408 was associated with DRB3*0202, while in Polynesians and Micronesians it was associated with DRB3*0101. The different haplotype arrangements, together with the near absence of DRB1*1408 in coastal Melanesians, suggest the possibility that two independent mutations have generated DRB1*1408 in Australia and Oceania. DRB1*1409 and 1410 alleles were confined to Australian Aborigines, while DRB1*1407 was found exclusively in Melanesians; DRB1*1401 was the only HLA‐DR6 allele represented in all study populations. The population‐specific HLA‐DR6 alleles and haplotypes have important implications for unrelated bonemarrow donor registries in Australia and Oceania.