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EXPRESSION OF A MHC NON‐CLASSICAL CLASS I GENE, 04, IS SIMILAR TO A CLASSICAL CLASS I GENE, D p
Author(s) -
Badley J.E.,
Frelinger J.A.
Publication year - 1991
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1991.tb00031.x
Subject(s) - gene , biology , transcription (linguistics) , genetics , gene expression , messenger rna , mhc class i , rna , microbiology and biotechnology , major histocompatibility complex , philosophy , linguistics
SUMMARY We have investigated the effects of the cell cycle on expression of Q4 mRNA. Q4 , the gene encoding the Qb‐1 antigen, is transcribed in a wide variety of tissues, unlike many other non‐classical class I genes. We have compared the pattern of Q4 transcription in the cell cycle to classical class I, β‐ 2 ‐microglobulin and actin. We found that the pattern of Q4 RNA levels resembles that of the classical class I genes, consistent with the similarity of the 5′sequences of Q4 and K/D. Thus, Q4 mRNA accumulates during the cell cycle along with the total RNA, but does not show specific transcriptional enhancement. This is consistent with a function for Q4 similar to the classical K/D gene products.