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APPLICATION OF POLYMERASE CHAIN REACTION (PCR) TO HLA‐C LOCUS TYPING
Author(s) -
Sakkas L. I.,
Vaughan R. W.,
Panayi G. S.,
Welsh K. I.
Publication year - 1991
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1991.tb00018.x
Subject(s) - polymerase chain reaction , typing , human leukocyte antigen , microbiology and biotechnology , polymerase , oligonucleotide , biology , chemistry , genetics , gene , antigen
SUMMARY Polymerase chain reaction/oligonucleotide typing was used to identify HLA‐Cw*0601 (Cw6) in patients with psoriasis and psoriatic arthritis. The assignment of HLA‐Cw*0601 was established by the concordant presence of codons for alanine (position 73), lysine (position 80) and tryptophan (position 97). The frequencies of all three codons were increased in the patient groups.