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A POTENTIAL WEAK ALLELIC DIFFERENCE IN MALE‐SPECIFIC ANTIGEN BETWEEN TWO INBRED STRAINS OF MICE
Author(s) -
Dresser D. W.
Publication year - 1991
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1991.tb00017.x
Subject(s) - spleen , biology , lymph node , inbred strain , allele , antigen , immunogenicity , chromosome , microbiology and biotechnology , lymphatic system , immunology , balb/c , c57bl/6 , gene , genetics , immune system
SUMMARY Differences were detected between male‐specific antigen(s) from BALB/c and C57BL/10 mice. Reciprocal crosses between these strains were analysed by means of a popliteal lymph node assay enumerating cells secreting IgM and IgG in a T‐dependent bystander B‐cell response. The responses, while being indirect, weak and variable, suggested that there are differences in ‘immunogenicity’ coded by Y‐linked (male‐specific) genes. This conclusion was strengthened by the results of experiments carried out in Y‐backcross mice, where spleen cells from male C57BL mice with a BALB/c‐Y (B10.C‐Y C ) stimulated low popliteal lymph node responses in female littermates in comparison with C57BL mice with their own Y‐chromosome. In contradistinction, male spleen cells from a BALB/c with a C57B1/10‐Y chromosome (C.B10‐Y B ), injected into a hind footpad of a female littermate, induced a relatively higher popliteal lymph node response.