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POST‐TRANSLATIONAL POLYMORPHISM OF HUMAN IgA IDENTIFIED BY IMMUNOISOELECTROFOCUSING
Author(s) -
Benedictis G. De,
Rose G.,
Brancfti C.
Publication year - 1990
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1990.tb00858.x
Subject(s) - sialic acid , glycoprotein , neuraminidase , sialyltransferase , gene , polymorphism (computer science) , biology , genetics , allele , virus
SUMMARY Immunoisoelectrofocusing (IIEF) reveals a microheterogeneity of human serum IgA controlled by an autosomal polymorphic gene, termed S . The microheterogeneity disappears when sialic acid is removed from serum glycoproteins by neuraminidase treatment. It can be postulated, therefore, that S encodes a sialyltransferase which attaches sialic acid at the outer prosthetic chains of IgA.