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VARIANTS OF Mta, THE MOUSE MATERNALLY TRANSMITTED ANTIGEN, DETERMINED BY THREE ALLELES OF THE EXTRACHROMOSOMAL GENE Mtf
Author(s) -
Lindahl K. Fischer,
Hausmann B.,
Guénet J.L.
Publication year - 1990
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1990.tb00857.x
Subject(s) - extrachromosomal dna , allele , genetics , gene , biology , antigen , microbiology and biotechnology , genome
SUMMARY Two new forms of Mta, the maternally transmitted antigen of the mouse, were defined by cytotoxic T lymphocytes. One is found in laboratory mice carrying the β allele of the maternally transmitted factor, Mtf , which were previously thought to be Mta‐negative. The other is associated with a new allele, Mtf γ , and is found in wild mice from Toulouse. Like the common form of Mta, determined by the extrachromosomal Mrf α , the new forms are also dependent on the α allele of Hmt , a chromosomal gene linked to H‐2 . and are associated with β 2 ‐microglobulin. Killers could be raised in all six combinations of a, β, and γ mice, showing that each form of Mtf determines a distinct (set of) epitope(s). We propose that the product of the Hmt gene, a class I MHC antigen, presents a peptide derived from a mitochondrial gene product on the cell surface and thereby creates the target antigen, Mta.