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SUSCEPTIBILITY EPITOPE ON HLA‐DR β CHAIN FOR RHEUMATOID ARTHRITIS AND THE EFFECT OF THE POSITIVITY ON THE CLINICAL FEATURES
Author(s) -
Takeuchi F.,
Matsuta K.,
Watanabe Y.,
Tokunaga K.,
Juji T.,
Miyamoto T.
Publication year - 1989
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1989.tb00497.x
Subject(s) - rheumatoid arthritis , medicine , rheumatoid factor , epitope , incidence (geometry) , immunology , gastroenterology , polymerase chain reaction , genetics , antibody , gene , biology , optics , physics
SUMMARY A highly significant association of an amino acid sequence, ‘ 70 Q 71 R 72 R 73 A 74 A’ located on the DRβ‐1 chain, with rheumatoid arthritis (RA) was confirmed in Japanese patients using polymerase chain reaction. The ‘ 70 QRRA 74 A’ is the most plausible candidate of susceptibility epitope in Japanese RA patients. The patients carrying the sequence showed slightly higher but not significant familial incidence. The positivity of the ‘QRRAA’ showed no effect on the positivity of the rheumatoid factor, rheumatoid nodules, and extra‐articular signs. Also no significant differences in other clinical parameters (ESR, CRP, Hb, A/G) and age at onset were observed regarding the positivity. The risk that the ‘QRRAA’ positive subjects would suffer from RA was estimated to be about 1.3% which meant 7.2 times easier to get RA than those without ‘QRRAA’.