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MHC CLASS I EXPRESSION ON HUMAN TUMOUR CELLS AND THEIR SUSCEPTIBILITY TO NK LYSIS
Author(s) -
Pena J.,
Solana R.,
Alonso M. C.,
Santamaria M.,
Serrano R.,
Ramirez R.,
Carracedo J.
Publication year - 1989
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1989.tb00488.x
Subject(s) - major histocompatibility complex , mhc class i , biology , natural killer cell , interferon , k562 cells , immunology , interleukin 12 , interferon gamma , antigen , lymphokine activated killer cell , cytotoxic t cell , interleukin 21 , cancer research , cytokine , cd8 , in vitro , genetics , leukemia
SUMMARY Although natural killer (NK) activity is not restricted by the major histocompati‐bility complex (MHC), it has been suggested that the level of expression of MHC antigens by target cells may influence their lysis by NK cells. We have studied the NK susceptibility of 20 cell lines obtained from primitive and metastatic human tumours and the K562 cell line treated with γ‐interferon, phorbol ester TPA and tumour factor NK‐RIF. When the levels of MHC class I antigen expression on the human tumour cell lines and their NK susceptibility were compared, no relationship between these two parameters was observed. Futhermore the treatment of K562 with either γ‐interferon, TPA or NK‐RIF decreased its NK susceptibility independently of MHC class I expression. These results indicate that the MHC class I antigen is not the only factor directly involved in NK susceptibility and suggest that other membrane structures modulated by γ‐interferon, TPA or NK‐RIF may also influence NK susceptibility.