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IMMUNOGENETIC STUDIES OF SPONTANEOUS ABORTION IN MICE: III. NON‐H‐2 ANTIGENS AND GESTATION
Author(s) -
Bobé P.,
Kiger N.
Publication year - 1989
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1989.tb00465.x
Subject(s) - spleen , antigen , gestation , biology , fetus , andrology , immunology , pregnancy , resorption , endocrinology , genetics , medicine
SUMMARY CBA/J (H‐2 k ) females, mated with DBA/2 J (H‐2 d ) or DBA/1 J (H‐2 q ) males, exhibit a high rate of fetal resorption. In contrast, when H‐2 identical CBA substrains (i.e. CBA/Ca and CBA/N) are used, this phenomenon is not observed. On the other hand, before mating with DBA/2 J males, pre‐immunization of CBA/J females with spleen cells coming from BALB/c J or (DBA/2 x BALB/c J) F1 males (and not from other H‐2 d identical males whatever their Mls alleles) has significantly decreased the fetal resorption rate. Thus, immunization against determinants other than classical H‐2 d (K, I, D, L) antigens (transmitted as a dominant character and different from Mls determinants) can elicit anti‐abortive effects. Furthermore, it was observed that the spleen cell endowed with the anti‐abortive effects was neither a T nor a B lymphocyte. In contrast, peritoneal cells were able to reproduce the phenomenon, indicating that it may be mediated by a cell of the macrophage‐monocyte lineage. Finally, a first gestation was substituted for allo‐immunization of CBA/J females. The anti‐abortive effects of a first pregnancy by BALB/c J males (and not by other H‐2 k syngeneic or H‐2 d allogeneic males) was observed in the course of a second pregnancy sired by DBA/2 J males. These data can be interpreted in terms of maternal recognition of an antigen present on both macrophages and trophoblast cells and necessary for a successful gestation, which is coded for by genes outside the K, I, D, L regions.