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GROSS GENETIC DIFFERENCES AMONG SUBSTRAINS OF NZB MICE
Author(s) -
Weiss S.,
Uematsu Y.,
D'Hoostelaere L.,
Alanen A.
Publication year - 1989
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1989.tb00464.x
Subject(s) - biology , haplotype , southern blot , microbiology and biotechnology , phenotype , western blot , genetics , strain (injury) , mouse strain , gene , genotype , anatomy
SUMMARY Substrains of NZB mice have been compared by Southern blot analysis using several probes. The restriction fragment length polymorphism of probes derived from the Igh‐V, Igk‐V, Tcrα‐C loci and of the long terminal repeat of the mouse mammary tumour virus revealed that NZB/BlLwPtIbm were grossly different from NZB/BlNJ and NZB/BlOla. Comparison with mouse strains of the Igk‐V haplotypes a and d suggested that NZB/BiLwPtIbm contain genetic material of the C58 mouse strain.