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TUMORIGENIC AND METASTATIC ABILITY OF SV40‐TRANSFORMED BALB/c CELL LINES AND MHC ANTIGEN EXPRESSION
Author(s) -
Giovanni C. De,
Nicoletti G.,
Re B. Del,
Scotlandi K.,
Prodi G.,
Lollini P.L.,
Nanni P.
Publication year - 1989
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1989.tb00446.x
Subject(s) - antigen , biology , major histocompatibility complex , in vivo , cancer research , cell culture , mhc class i , metastasis , mhc class ii , immunology , cancer , genetics
SUMMARY Tumorigenic and metastatic potential were studied in relation to class I MHC expression in four different SV40‐transformed BALB/c cell lines. All the lines studied, tumorigenic or not, expressed both H‐2K d and D d , so MHC antigens did not seem to be involved in the control of SV40‐transformed cells' growth in vivo . Lung metastases were observed in all tumour‐bearing mice. Cells cultured after in vivo passage, obtained either from tumour tissue or from individual lung metastases, still expressed similar levels of H‐2 d antigens, thus suggesting that tumour growth and metastasis do not occur through the selection of variants with altered MHC expression.