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GENETIC CONTROL OF C3 PRODUCTION BY THE S REGION OF THE MOUSE MHC
Author(s) -
Dieli F.,
Lio D.,
Sireci G.,
Salerno A.
Publication year - 1988
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1988.tb00437.x
Subject(s) - congenic , haplotype , major histocompatibility complex , biology , complement (music) , genetics , gene , allele , phenotype , complementation
SUMMARY The present paper reports evidence indicating that the level of the third complement component (C3) is regulated by the S region of the murine H‐2 complex. In fact, using congenic strains of mice we demonstrate that mice with the k haplotype at the S region show high C3 levels, whereas mice with the d haplotype at the S region show low C3 levels.