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ALPHA‐1‐ANTITRYPSIN (Pi) TYPES IN MULTIPLE SCLEROSIS AND LACK OF INTERACTION WITH IMMUNOGLOBULIN (GM) MARKERS
Author(s) -
Francis D. A.,
Klouda P. T.,
Brazier D. M.,
Batchelor J. R.,
McDonald W. I.,
Hern J. E. C.
Publication year - 1988
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1988.tb00428.x
Subject(s) - antibody , pi , multiple sclerosis , alpha (finance) , immunoglobulin g , immunology , biology , medicine , biochemistry , construct validity , nursing , patient satisfaction
SUMMARY Susceptibility to multiple sclerosis is thought to involve several genetic loci apart from the HLA region on chromosome 6. No Pi allotype nor phenotype was associated with the disease in 125 unrelated patients from the Grampian region of northeast Scotland. Despite a previously reported Gm‐HLA association in this population there was no apparent interaction between Pi alleles and Gm type which influenced disease susceptibility.