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DIFFERENTIAL EXPRESSION OF THE ASGM 1 ANTIGEN ON ANTI‐REOVIRUS AND ALLOREACTIVE CYTOTOXIC T LYMPHOCYTES (CTL)
Author(s) -
Parker S. E.,
Sun Y. H.,
Sears D. W.
Publication year - 1988
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1988.tb00424.x
Subject(s) - ctl* , cytotoxic t cell , biology , lytic cycle , antigen , virology , immunology , lymphokine , t lymphocyte , virus , cd8 , in vitro , genetics
SUMMARY Anti‐reovirus cytotoxic effectors were found to be: (i) H‐2 restricted; (ii) virus specific; (iii) non‐lytic (in 4 h) for natural killer (NK)‐sensitive YAC‐1 cells; and (iv) positive for the Thy‐1 and Lyt‐2 lymphocyte markers. Thus, anti‐reovirus cytotoxic effectors have the functional and phenotype characteristics of cytotoxic T lymphocyte (CTL). A significant fraction of anti‐viral CTL, as well as alloreactive CTL, were also found to be positive for the asialo GM 1 (ASGM 1 ) cell surface antigen, generally considered to be a NK cell marker. ASGM 1 expression on these CTL, as determined by sensitivity to antibody plus complement (C), appeared to be highly variable and dependent on two factors—the nature of the antigenic stimulus (viral vs. alloantigen), and the mouse strain from which the CTL originated. Thus, ASGM 1 antigen expression on CTL appears to be regulated and may be under the control of lymphokines, development differentiation signals and/or other strain‐dependent genetic factors.