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AN EXTERNAL STIMULUS THAT MIMICS Mls LOCUS RESPONSES
Author(s) -
Janeway C. A.,
Chalupny J.,
Conrad P. J.,
Buxser S.
Publication year - 1988
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1988.tb00418.x
Subject(s) - locus (genetics) , biology , t cell receptor , receptor , major histocompatibility complex , stimulus (psychology) , polyclonal antibodies , t cell , microbiology and biotechnology , antigen , genetics , gene , immune system , psychology , psychotherapist
SUMMARY The response to a novel set of T cell mitogens has been analysed and compared to the response to Mls locus differences. These polyclonal T cell activators, staphylococcal enterotoxins A and B, stimulate T cells in a way that requires an antigen‐presenting cell bearing class II MHC products and involves the CD4:T cell receptor complex. However, the specificity of MHC recognition by the T cell receptor is lost in this response. Thus, these mitogens produce a response with characteristics similar to that induced by Mls locus differences. These mitogens can be used to analyse the immunobiology of this response, and may help in understanding and identifying the Mls locus product as well.