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MULTIDIRECTIONAL INTERACTIONS IN AN Mls‐DISPARATE RESPONSE
Author(s) -
Goldbach J.,
Kirchner H.,
Kölsch E.
Publication year - 1988
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1988.tb00416.x
Subject(s) - biology , microbiology and biotechnology , clone (java method) , spleen , stimulation , mediator , regulator , cell culture , immunology , genetics , gene , neuroscience
SUMMARY The murine T cell clone E11, isolated from a primary H‐2 k ‐histocompatible, one‐way mixed lymphocyte culture of B10.BR anti‐C3H/Tif spleen cells, has been used to analyse multidirectional interactions in Mil‐disparate responses. Several events can be observed. There is proliferation of T cells upon stimulation by macrophages or B cells of Mls‐disparate stimulator cells. In addition, one finds induction of differentiation of B cells of stimulator strains. E11 T cells inhibit spreading and differentiation of macrophages of stimulator strains and also prevent the production of a T cell growth‐supporting mediator by Mls‐disparate spleen cells. All these phenomena can be explained by Mls a,d,c ‐specific induction of gamma‐interferon (γ‐IFN) production in the responder B10.BR (Mls b ) E11 T cells. It is suggested that γ‐IFN, as a regulator of feedback mechanisms, plays an essential role in Mls‐disparate cell interactions.