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A COMMENT ON H‐2‐RESTRICTED T CELL RECOGNITION OF Mls DETERMINANTS: A QUESTION OF PERSPECTIVE
Author(s) -
Peck A. B.
Publication year - 1988
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1988.tb00410.x
Subject(s) - locus (genetics) , biology , major histocompatibility complex , genetics , phenotype , antigen , gene
SUMMARY Data presented here address the question of whether T lymphocyte recognition of Mis determinants is MHC restricted. Using isolated T cell blasts from primary MLCs involving H‐2‐identical, Mls‐disparate strain combinations as responding cell populations in secondary MLCs, and measuring their responses against fresh stimulating cells from different strains, has permitted the study of reactions towards Mis determinants in the presence of MHC antigenic differences. Results strongly suggest that recognition of Mls c ( Mls‐2 locus) determinants is H‐2 restricted. In contrast, there is still little evidence that the recognition of Mls a ( Mls‐1 locus) determinants is H‐2 restricted. Furthermore, data are also presented which refute the notion that different H‐2 haplotypes possess different abilities to present Mls a determinants to responding T cells.