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THE RELATIONSHIP OF Mls x TO Mls c
Author(s) -
AbromsonLeeman S. R.,
Laning J. C.,
Crowell J.,
Dorf M. E.
Publication year - 1988
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1988.tb00404.x
Subject(s) - physics , chemistry
SUMMARY Among T cell clones with specificity for cow insulin and autologous class II MHC products, a significant number displayed interesting patterns of alloreactivity to non‐MHC antigens. Four clones are described in this report. One is a typical Mls a ‐reactive clone, while the other three proliferate to a variety of allogeneic spleen cells with reportedly different Mls phenotypes. These include PL/J stimulator cells, designated Mls x all strains reported to be Mls c , and several strains previously typed as Mls a . Little is known about Mls x except that it does not appear to be cross‐reactive with Mls a . In this report, therefore, we attempt to investigate the reasons why these clones seem to be stimulated by a variety of different Mls phenotypes. Our conclusions are, first, that some of the strains previously typed as Mls a may actually express a second Mls product, either c or x, in a manner analogous to the CBA/J strain (which expressess both Mls a and Mls c ), and second, that Mls c and Mls x are cross‐reactive. In preliminary experiments, we investigate the genetic relationship between Mls c and Mls x by analysis of backcrosses, and the extent of cross‐reactive recognition of Mls c and Mls x by raising T cell clones which recognize one but not the other. Our preliminary conclusion is that Mls c and Mls x are cross‐reactive, but represent distinct gene products.