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A REAPPRAISAL OF Mls GENETICS
Author(s) -
Abe R.,
Hodes R. J.
Publication year - 1988
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1988.tb00402.x
Subject(s) - locus (genetics) , genetics , biology , gene , allele , encode
SUMMARY Although the minor lymphocyte stimulatory locus ( Mls ) system was originally described as a single‐locus, multiple‐allelic system, allelism among the genes which encode Mls a , Mls c and Mls d has not been demonstrated formally. In this report, genetic linkage between genes encoding Mls a and Mls c was studied by testing responses of unprimed T cells, as well as Mls a ‐ and Mls c ‐specific T cell clones, to the progeny of (AKR/J × C3H/HeJ) F 1 × B10.BR [( Mls a × Mls c )F 1 × Mls b ] crosses. In addition, the configuration of Mls genes expressed by CBA/J ( Mls d ) was evaluated by examining the response pattern of a panel of Mls d ‐specific clones to (CBA/J × B10.BR)F 1 × B10.BR stimulators. Results of these segregation analyses indicated that the Mls system is composed of at least two independent and unlinked genes which encode, respectively, the determinants identified as Mls a and Mls c .