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VITAMIN A‐ENHANCED CLEFT PALATE SUSCEPTIBILITY ASSOCIATED WITH H‐2
Author(s) -
Tyan M. L.
Publication year - 1987
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1987.tb00386.x
Subject(s) - congenic , dexamethasone , biology , allele , vitamin , locus (genetics) , pregnancy , medicine , endocrinology , gene , genetics
SUMMARY Pregnant mice from the congenic strains C57BL/10Sn, B10.BR, B10.A/SgSn, B10.A(SR)/SgSn, B10.A(2R)SgSn and B10.A(18R)Sg were fed Purina Laboratory Chow or the same diet plus approximately 400IU vitamin A daily and given 80 mg/kg dexamethasone intra‐peritoneally or a sham injection on the 12th day of pregnancy. It was found that only strains with b alleles between H‐2S and H‐2D had significantly higher frequencies of isolated cleft palate among their progeny when fed the supplemental vitamin A. The locus appears to be on the centromeric side of a dexamethasone‐induced cleft palate gene which has been mapped to the same general area.