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A GENE LOCUS CONTROLLING A SERUM PROTEIN MIGRATING ELECTROPHORETICALLY IN THE β REGION OF MICE AND DETECTED BY USING A STRAIN DERIVED FROM THE JAPANESE WILD MOUSE (MUS MUSCULUS MOLOSSINUS)
Author(s) -
Harada YoshiNobu,
Hayakawa JunIchiro,
Noda Eiko,
Tomita Takeshi
Publication year - 1987
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1987.tb00361.x
Subject(s) - locus (genetics) , biology , gene , microbiology and biotechnology , antigen , genetic linkage , genetics , strain (injury) , balb/c , ratón , immunology , anatomy , immune system
SUMMARY Antigenic specificities of serum proteins from the MOL‐ANJ strain of mice (a strain derived from Japanese wild mice, Mus musculus molossinus ) were studied by gel precipitation with alloantisera produced by reciprocal alloimmunization between MOL‐ANJ and BALB/c mice. An alloantigen which migrates immuno‐electrophoretically in the β region of serum proteins has been identified. Evidence indicates that this antigenic specificity is controlled by a co‐dominant autosomal gene locus designated by the symbol Sas‐2. The evidence also suggests that Sas‐2 is genetically different from the previously described Sus‐1 which controls a serum protein in the mouse. Sas‐2 was located by linkage analysis between Zdh‐1 locus and Akp‐1 locus on chromosome 1.