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GENES WITHIN THE MAJOR HISTOCOMPATIBILITY COMPLEX INFLUENCE THE RESPONSE TO AMPICILLIN THERAPY AND SEVERITY OF RELAPSE IN H‐2 CONGENIC, SUSCEPTIBLE Ity s MICE INFECTED WITH VIRULENT SALMONELLA TYPHIMURIUM
Author(s) -
Maskell D. J.,
Hormaeche C. E.
Publication year - 1986
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1986.tb01129.x
Subject(s) - virulence , congenic , biology , microbiology and biotechnology , major histocompatibility complex , salmonella , ampicillin , gene , typhoid fever , virology , immunology , bacteria , genetics , antibiotics
SUMMARY Control by genes within H‐2 of natural resistance to fully virulent salmonellae in susceptible mice was studied by the typhoid relapse model. Susceptible ( Ity s ), H‐2 congenic C57BL/10 (B10) lines were infected with a lethal dose of the virulent S. typhimurium C5 and rescued from death by ampicillin therapy, inducing a chronic infection. The response to therapy and its cessation, both early and late in the infection, varied in different strains. B10 ( H‐Z b ) and B10.D2 ( H‐2 d ) responded less well to therapy, and were more prone to relapse on its removal, than B10.A (H‐2 a ) or B10.M (H‐2 f ) mice. This haplotype distribution is the same as that previously reported for H‐2 linked resistance and susceptibility of similar mice to salmonellae of low virulence. The results indicate that resistance to a virulent salmonella capable of causing natural infection is influenced by genes within the MHC.