Premium
MATERNAL IMMUNOGLOBULIN ALLOTYPE (GM AND KM) AND NEONATAL GROUP B STREPTOCOCCAL INFECTION
Author(s) -
Thom H.,
Lloyd D. L.,
Reid T. M. S.
Publication year - 1986
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1986.tb01115.x
Subject(s) - allotype , group b , incidence (geometry) , group a , immunology , phenotype , antibody , immunity , biology , immune system , medicine , genetics , gene , physics , optics
SUMMARY Gm and Km(1) allotypes in 37 mothers of neonates with severe Group B streptococcal (GBS) infection were compared with 115 mothers of non‐infected infants, 36 of whom were known to be colonized with GBS. Deficits in Glm(1) and Km(l), and an increased incidence of G2m(23), were found in mothers of infected infants. Km(1) was associated mainly with the phenotype Gm(1, (2), 3, 17; 23; 5, 10, 11, 21) in mothers of infected infants while being uniformly distributed in mothers of non‐infected infants. This study would seem, therefore, to support reports of Gm and Km(1) allotype involvement in maternal response to GBS infection and immunity in the new‐born.