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MANIPULATION OF METASTASIS AND TUMOUR GROWTH BY TRANSFECTION WITH HISTOCOMPATIBILITY CLASS I GENES
Author(s) -
Hammerling G. J.,
Klar D.,
Katzav S.,
Segal S.,
Feldman M.,
Wallich R.,
Hämmerling A.
Publication year - 1986
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.1986.tb01096.x
Subject(s) - transfection , major histocompatibility complex , histocompatibility , gene , metastasis , biology , immunology , cancer research , class (philosophy) , genetics , human leukocyte antigen , antigen , cancer , philosophy , epistemology
SUMMARY Approximately 50% of fibrosarcomas induced with methylcholanthrene A were found to be defective in H‐2 expression. In tumours which lack H‐2K antigens, H‐2 gene transfection was used to restore H‐2K expression. The de novo expression of H‐2K reduced tumorigenicity and abolished the formation of metastases in syngeneic mice. Expression of H‐2K seems to render the tumour cells immunogenic and leads to effective recognition of the tumour cells by the host immune system.